What Causes It?
Genetic mutations affecting adrenal cells
Family history of endocrine tumors (e.g., MEN syndromes)
Hormonal imbalances
Previous cancer spreading to adrenal glands (metastasis)
Chronic stress and prolonged high cortisol levels
Inherited conditions such as Li-Fraumeni syndrome
Unknown (idiopathic) causes in many benign tumors
Signs & Symptoms
High blood pressure (hypertension)
Unexplained weight gain or loss
Excessive hair growth (hirsutism)
Fatigue and muscle weakness
Sweating, rapid heartbeat, and anxiety
Headaches (often in pheochromocytomas)
Abdominal pain or fullness
Stretch marks on the skin (in cortisol-producing tumors)