What Causes It?
Genetic mutations - Inherited mutations in certain genes, particularly BRCA1 and BRCA2, significantly increase breast cancer risk. These account for 5-10% of breast cancers.
Family history - Having first-degree relatives (mother, sister, daughter) with breast cancer approximately doubles the risk, especially if they were diagnosed before age 50.
Personal history - Women who have had breast cancer in one breast have a higher risk of developing it in the other breast or a different part of the same breast.
Dense breast tissue - Having dense breasts (more glandular and fibrous tissue and less fatty tissue) increases breast cancer risk and makes detection on mammograms more difficult.
Age - Risk increases with age, with most breast cancers diagnosed in women over 50.
Reproductive history - Factors that increase lifetime exposure to estrogen, such as early menstruation (before age 12), late menopause (after 55), not having children, or having first child after age 30, slightly increase risk.
Hormone therapies - Combined hormone replacement therapy for menopausal symptoms and certain oral contraceptives slightly increase breast cancer risk during use.
Radiation exposure - Previous chest radiation, especially at a young age (such as for Hodgkin's lymphoma), increases breast cancer risk.
Lifestyle factors - Obesity (particularly after menopause), physical inactivity, alcohol consumption, and smoking are associated with increased risk.
Previous breast conditions - Certain benign breast conditions, such as atypical hyperplasia, can increase risk.
Signs & Symptoms
A new lump or mass in the breast or underarm area
Thickening or swelling of part of the breast
Dimpling or irritation of breast skin
Redness or flaky skin in the nipple area or the breast
Pulling in of the nipple (retraction) or pain in the nipple area
Nipple discharge other than breast milk, including blood
Changes in the size or shape of the breast
Pain in any area of the breast
Swelling of all or part of the breast (even if no lump is felt)
Skin changes resembling an orange peel (peau d'orange)
Breast or nipple pain
Swollen lymph nodes in the armpit
Many women have no symptoms, which is why regular screening is important