What Causes It?
Genetic factors - Mutations in genes responsible for maintaining a healthy skin barrier, particularly the filaggrin gene, can make the skin more vulnerable to irritants and allergens.
Immune system dysfunction - An overactive immune response can trigger inflammation in the skin when exposed to certain substances.
Environmental triggers - Various external factors can worsen symptoms, including harsh soaps, detergents, certain fabrics, temperature extremes, and humidity changes.
Allergies - Many people with eczema also have food or environmental allergies that can trigger flare-ups.
Skin barrier dysfunction - The outermost layer of skin (stratum corneum) functions poorly in people with eczema, allowing moisture to escape and irritants to enter more easily.
Stress - Emotional stress can trigger or worsen eczema symptoms through immune system alterations and increased inflammation.
Microbiome imbalance - Changes in the normal balance of bacteria on the skin may contribute to eczema development and severity.
Hormonal changes - Some women experience eczema flares related to hormonal fluctuations during pregnancy, before menstrual periods, or during menopause.
Signs & Symptoms
Dry, sensitive skin that may appear reddened or inflamed
Intense itching, especially at night
Red to brownish-gray patches, particularly on the hands, feet, ankles, wrists, neck, upper chest, eyelids, inside the elbows, and behind the knees
Small, raised bumps that may leak fluid and crust over when scratched
Thickened, cracked, or scaly skin
Raw, sensitive skin from scratching
Skin infections due to broken skin from frequent scratching
Sleep disturbances due to itching
Symptom flare-ups followed by periods of remission
In infants, rashes commonly appear on the scalp and cheeks and may bubble up before leaking fluid
Darkening of the skin around the eyes or eyelids
Changes in skin color after inflammation subsides (either lightening or darkening)