What Causes It?
Genetic factors - Fibroids may develop when a muscle cell in the uterus multiplies excessively, creating a benign tumor. Genetic alterations have been found in fibroid cells that differ from those in normal uterine muscle cells.
Hormonal influences - Estrogen and progesterone appear to promote fibroid growth. Fibroids contain more estrogen and progesterone receptors than normal uterine muscle cells and tend to shrink after menopause when hormone levels decrease.
Growth factors - Substances that help the body maintain tissues, such as insulin-like growth factor, may affect fibroid growth.
Extracellular matrix (ECM) - This material, which makes cells stick together like mortar between bricks, is increased in fibroids and makes them fibrous.
Family history - Having a mother or sister with fibroids increases your risk.
Race - Women of African ancestry are more likely to develop fibroids and at an earlier age.
Early onset of menstruation - Beginning menstruation at an early age increases lifetime exposure to estrogen.
Obesity - Women with obesity have higher estrogen levels, which may contribute to fibroid development.
Vitamin D deficiency - Some research suggests a link between vitamin D deficiency and fibroid development.
Diet - Red meat consumption has been associated with increased risk, while green vegetables may be protective.
Signs & Symptoms
Heavy menstrual bleeding (menorrhagia) - Periods lasting more than a week or requiring frequent changing of pads/tampons.
Pelvic pressure or pain - A feeling of fullness or pressure in the lower abdomen.
Frequent urination - Due to fibroids pressing on the bladder.
Difficulty emptying the bladder - Complete emptying may be hindered by large fibroids.
Constipation - Fibroids pressing on the rectum can cause constipation or difficult bowel movements.
Backache or leg pain - Fibroids pressing on nerves or muscles in the back or legs.
Pain during intercourse - Depending on the location of fibroids.
Prolonged menstrual periods - Often with excessive bleeding, sometimes with clots.
Reproductive problems - Including infertility, multiple miscarriages, or early onset of labor during pregnancy.
Abdominal swelling - The abdomen may appear enlarged, similar to early pregnancy, with large fibroids.