What Causes It?
Excess cholesterol in bile that crystallizes to form stones
Excess bilirubin in bile (often due to liver conditions or blood disorders)
Insufficient bile salts to dissolve cholesterol in bile
Concentration of bile due to inadequate gallbladder emptying
Genetic predisposition to gallstone formation
Female gender (women are twice as likely to develop gallstones)
Age over 40
Obesity or rapid weight loss
High-fat, high-cholesterol, low-fiber diet
Diabetes and metabolic syndrome
Certain medications (including hormone therapy and cholesterol-lowering drugs)
Pregnancy and elevated estrogen levels
Signs & Symptoms
Sudden, intensifying pain in the upper right abdomen (biliary colic)
Pain that may radiate to the right shoulder or back
Pain after meals, particularly fatty foods
Nausea and vomiting
Fever and chills (if infection is present)
Jaundice (yellowing of the skin and eyes) if bile ducts are blocked
Clay-colored stools
Indigestion, bloating, and gas
Many people with gallstones remain asymptomatic until complications occur
Episodes of pain typically last 1-4 hours
Complications may include cholecystitis (gallbladder inflammation), cholangitis (bile duct infection), or pancreatitis