Endometriosis

Endometriosis is a condition in which tissue similar to the lining of the uterus (the endometrium) grows outside the uterus. Endometriosis most commonly involves the ovaries, fallopian tubes, and the tissue lining the pelvis. Rarely, endometrial-like tissue may be found beyond the area where pelvic organs are located. With endometriosis, the endometrial-like tissue acts as endometrial tissue would — it thickens, breaks down, and bleeds with each menstrual cycle. But because this tissue has no way to exit the body, it becomes trapped. When endometriosis involves the ovaries, cysts called endometriomas may form. Surrounding tissue can become irritated, eventually developing scar tissue and adhesions — bands of fibrous tissue that can cause pelvic tissues and organs to stick to each other.

Endometriosis

Causes

  • Retrograde menstruation - In retrograde menstruation, menstrual blood containing endometrial cells flows back through the fallopian tubes and into the pelvic cavity instead of out of the body. These endometrial cells stick to the pelvic walls and surfaces of pelvic organs, where they grow and continue to thicken and bleed over the course of each menstrual cycle.
  • Transformation of peritoneal cells - In what's known as the "induction theory," experts propose that hormones or immune factors promote transformation of peritoneal cells — cells that line the inner side of your abdomen — into endometrial-like cells.
  • Embryonic cell transformation - Hormones such as estrogen may transform embryonic cells — cells in the earliest stages of development — into endometrial-like cell implants during puberty.
  • Surgical scar implantation - After a surgery, such as a hysterectomy or C-section, endometrial cells may attach to a surgical incision.
  • Endometrial cell transport - The blood vessels or tissue fluid (lymphatic) system may transport endometrial cells to other parts of the body.
  • Immune system disorder - A problem with the immune system may make the body unable to recognize and destroy endometrial-like tissue that's growing outside the uterus.
  • Genetic factors - Endometriosis can run in families, suggesting a genetic component to the condition.
  • Environmental factors - Exposure to certain environmental toxins, such as dioxin, may affect the body's immune system and hormonal regulation, potentially contributing to endometriosis.
  • Complications from prior uterine infections - Some research suggests that endometriosis could be linked to complications from prior uterine infections.
  • Autoimmune disorders - Some women with endometriosis also have other autoimmune disorders, suggesting a possible link between endometriosis and immune system dysfunction.

Signs and Symptoms

  • Painful periods (dysmenorrhea) - Pelvic pain and cramping may begin before and extend several days into a menstrual period. You may also have lower back and abdominal pain.
  • Pain with intercourse - Pain during or after sex is common with endometriosis.
  • Pain with bowel movements or urination - You're most likely to experience these symptoms during a menstrual period.
  • Excessive bleeding - You may experience occasional heavy menstrual periods or bleeding between periods (intermenstrual bleeding).
  • Infertility - Sometimes, endometriosis is first diagnosed in those seeking treatment for infertility.
  • Other signs and symptoms - You may experience fatigue, diarrhea, constipation, bloating or nausea, especially during menstrual periods.
  • Chronic pelvic pain - Pain in the lower abdomen or pelvis that lasts for six months or more.
  • Painful ovulation - Some women experience pain during ovulation, which occurs in the middle of the menstrual cycle.
  • Pain during physical activities - Activities that put pressure on the pelvis, such as exercise or sitting for long periods, may cause discomfort.
  • Digestive issues - Symptoms like diarrhea, constipation, bloating, or nausea that worsen during menstrual periods.

Diagnosis

Pelvic Exam

During a pelvic exam, your doctor manually feels (palpates) areas in your pelvis for abnormalities, such as cysts on your reproductive organs or scars behind your uterus. Often, however, it's not possible to feel small areas of endometriosis unless they've caused a cyst to form.

Ultrasound

This test uses high-frequency sound waves to create images of the inside of your body. To capture the images, a device called a transducer is either pressed against your abdomen or inserted into your vagina (transvaginal ultrasound). Standard ultrasound imaging doesn't definitively tell your doctor whether you have endometriosis, but it can identify cysts associated with endometriosis (endometriomas).

Magnetic Resonance Imaging (MRI)

An MRI provides detailed images of your organs and tissues using a magnetic field and radio waves. This test can help your doctor identify endometriosis implants, especially those that are deep within your tissue.

Laparoscopy

In some cases, your doctor may refer you to a surgeon for a procedure that allows the surgeon to view inside your abdomen (laparoscopy). While you're under general anesthesia, your surgeon makes a tiny incision near your navel and inserts a slender viewing instrument (laparoscope), looking for signs of endometrial tissue outside the uterus. A laparoscopy can provide information about the location, extent and size of the endometrial implants. Your surgeon may take a tissue sample (biopsy) for further testing.

CA-125 Test

This blood test measures a protein called CA-125, which is found in higher concentrations in people with endometriosis. However, this test isn't definitive, as CA-125 can be elevated for many reasons, and some people with endometriosis have normal CA-125 levels.

Treatment Options

Pain Medications

Over-the-counter pain medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), like ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve), may help ease painful menstrual cramps. If these don't help, your doctor might prescribe stronger pain medications or refer you to a pain specialist.

Hormone Therapy

Supplemental hormones can sometimes be effective in reducing or eliminating the pain of endometriosis. Hormone therapy helps your body regulate the monthly hormonal changes that promote the tissue growth that occurs when you have endometriosis. Options include hormonal contraceptives, gonadotropin-releasing hormone (Gn-RH) agonists and antagonists, progestin therapy, and aromatase inhibitors.

Fertility Treatment

If you're having difficulty becoming pregnant, your doctor may recommend fertility treatment, which could include fertility medications to stimulate ovulation or assisted reproductive technologies, such as in vitro fertilization, to help you become pregnant.

Home Remedies

Heat Therapy

Applying a heating pad, hot water bottle, or taking a warm bath can help relax pelvic muscles and reduce pain. Some people find alternating between heat and cold provides relief.

Regular Exercise

Physical activity may help ease pain and improve symptoms. Low-impact exercises like walking, swimming, or yoga can be particularly beneficial. Exercise helps by improving blood flow, reducing estrogen levels, and releasing endorphins, which are natural pain relievers.

Dietary Changes

Some research suggests that certain dietary choices may help manage endometriosis symptoms. Consider reducing intake of red meat, trans fats, and foods high in caffeine and alcohol. Increasing consumption of fruits, vegetables, whole grains, and foods rich in omega-3 fatty acids may help reduce inflammation.

Stress Reduction

Stress can worsen endometriosis symptoms. Techniques such as deep breathing, meditation, yoga, and progressive muscle relaxation may help manage stress and reduce pain.

Over-the-counter Pain Relievers

Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen can help reduce pain and inflammation. Take them as directed, and consult with a healthcare provider if you need to use them frequently.

Preventive Care

  • Regular gynecological check-ups to monitor symptoms and adjust treatment as needed.
  • Taking hormonal birth control as prescribed to manage symptoms.
  • Maintaining a healthy diet rich in fruits, vegetables, and whole grains.
  • Regular exercise to help maintain a healthy weight and reduce estrogen levels.
  • Avoiding excessive alcohol and caffeine, which can worsen symptoms.
  • Managing stress through relaxation techniques, counseling, or support groups.
  • Getting adequate sleep to help the body heal and manage pain.
  • Avoiding environmental toxins that may mimic estrogen, such as certain plastics and pesticides.
  • Consider pregnancy and breastfeeding if family planning aligns with your goals, as they may temporarily relieve symptoms.
  • Discussing with your doctor about long-term management strategies, as endometriosis is a chronic condition.

Surgical Options

Conservative Surgery (Laparoscopy)

A minimally invasive procedure where the surgeon removes endometriosis implants while preserving the uterus and ovaries. Small incisions are made in the abdomen, and a thin tube with a camera (laparoscope) is inserted to guide the surgeon in removing endometrial tissue. This approach is often recommended for women who want to become pregnant or experience significant pain despite other treatments.

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Hysterectomy

A surgical procedure to remove the uterus, and sometimes the ovaries and fallopian tubes as well. This is considered a last resort for women who have severe symptoms, haven't responded to other treatments, and don't want to become pregnant. It's important to note that even with a hysterectomy, endometriosis may still recur if some endometrial tissue is left behind.

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Laparotomy

A more invasive surgical procedure involving a larger incision in the abdomen to remove endometriosis implants, cysts, or scar tissue. This approach might be necessary for severe or extensive endometriosis that can't be adequately addressed with laparoscopy.

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