What Causes It?
Chronic alcohol abuse (alcoholic liver disease)
Chronic viral infections such as hepatitis B, C, and D
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH)
Autoimmune hepatitis
Inherited disorders such as hemochromatosis, Wilson's disease, and alpha-1 antitrypsin deficiency
Biliary diseases such as primary biliary cholangitis and primary sclerosing cholangitis
Prolonged exposure to certain toxins and medications
Cardiac cirrhosis due to chronic heart failure
Infections such as schistosomiasis (more common in developing countries)
Signs & Symptoms
Fatigue and weakness
Loss of appetite
Nausea
Easy bruising and bleeding
Jaundice (yellowing of the skin and eyes)
Itchy skin
Swelling in the legs, ankles, or abdomen (edema and ascites)
Spider-like blood vessels visible on the skin (spider angiomas)
Redness in the palms of the hands (palmar erythema)
Confusion, drowsiness, and slurred speech (hepatic encephalopathy)
Weight loss
Muscle cramps and pain
Bleeding varices (enlarged veins in the esophagus or stomach that can rupture)